|
KMID : 0382619840040020659
|
|
Hanyang Journal of Medicine
1984 Volume.4 No. 2 p.659 ~ p.669
|
|
|
Changes in Composition of Bile in Patients with Diseases of Biliary System
|
|
元致奎/Won, Chi Kyoon
李光洙/金振瑛/韓仲洙/高在炅/Lee, Kwang Soo/Kim, Jin Young/Han, Joong Soo/Koh, Jai Kyung
|
|
|
Abstract
|
|
|
The biliary composition or gallbladder bile obtained at surgery was compared in 25 normal control subjects without hepatobiliary and intestinal diseases (normal control bile), in 11 patients with gallbladder stone (GB stone bile), and in 4.patients with common bile duct stone (CBD stone bile). Bile samples were collected by aspirating the gallbladder with a syringe during laparotomy and analyzed for cholesterol, phospholipid, bile salts, bilirubin, protein, and total solids by microdetermination methods including thin layer chromatography. The results obtained were as follows:
1. Contents of cholesterol, phospholipid, total bile salts, bilirubin, protein, and total solids were significantly decreased in gallbladder bile of patients with GB and. CBD stones as compared with those of normal controls. The percent ratio of cholesterol to phospholipid or to bile salts was higher in gallstone than in normal control, but statistical significance was observed only in CBD stone. The results suggested that decreases in bile lipid contents as well as increases in the percent ratio of cholesterol to phospholipid or to bile salts were highly valuable to understand the changes in bile composition of gallbladder bile in patients with gallstone..
2. Plotting of bile composition on triangular coordinates of cholesterol, phospholipid and bile salts revealed that bile samples located outside of the micellar zone were found to be 1 out of 25 cases of normal controls (4%), 1 out of 11 cases of GB stone (9%), and 2 out of 4 cases of CBD stone (50%), indicating high significance of supersaturability of gallbladder bile with cholesterol in CBD stone.
3. Contents of dihydroxy and trihydroxy bile salts in gallbladder bile were significantly lower in patients with gallstone than in normal controls. Average value for the ratio of dihydroxy to trihydroxy bile salts appeared to be higher in patients with gallstone than in normal controls, but was statistically insignificant between two groups. The ratio of glyco to Mauro bile salts in gallbladder bile was observed to be lower in patients with gallstone than in normal controls, but its statistical significance was limited to CBD stone.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|